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    Vol 59, Issue 1, 2025

    Evaluation of Antipyretic and Antioxidant Activities of Ten Indigenous Medicinal Plants of Tirtajaya, Karawang Regency, West Java, Indonesia

    Updated:3 Mins Read
    Neni Sri Gunarti1, Maulana Yusuf Alkandahri2, Eko Sri Wahyuningsih1, Putri Agustina1, Iin Lidia Putama Mursal3, Himyatul Hidayah4 and Vera Nurviana5
    Author informationCitations

    1Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, INDONESIA

    2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, INDONESIA

    3Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, INDONESIA

    4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, INDONESIA

    5Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Bakti Tunas Husada, Tasikmalaya, INDONESIA

    Corresponding author.

    Correspondence: Dr. Maulana Yusuf Alkandahri Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, West Java, INDONESIA. Email: alkandahri@gmail.com

    Author Notes

    February 08, 2024; July 18, 2024; October 07, 2024.

    Copyright and License information

    Copyright Copyright © 2025 IJPER
    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
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    Published in: Indian Journal of Pharmaceutical Education and Research, 2025; 59(1): 252-263. Published online: 20 December 2024DOI: 10.5530/ijper.20256381

    ABSTRACT

    Aim

    This research aimed to explore the antipyretic and antioxidant activity of infusions of Chromolaena odorata (COI), Abelmoschus manihot (AMI), Annona muricata (AMCI), Allium ascalonicum (AAI), Carica papaya (CPI), Tamarindus indica (TII), Zingiber officinale (ZOI ), Abrus precatorius (API), Momordica charantia (MCI) and Strobilanthes crispus (SCI).

    Materials and Methods

    The antipyretic activity of plant infusions was tested using a peptone-induced rat model. The male rat used were divided into 32 groups for each test. Each group consisted of four rats, including a negative control, a positive control (paracetamol 150 mg/kg) and groups COI, AMI, AMCI, AAI, CPI, TII, ZOI, API, MCI and SCI, each administered doses of 100, 200 and 400 mg/kg. Initial rectal temperature was recorded using a rectal thermometer at a depth of 1.5 cm in the rat rectum. Fever induction was confirmed by a temperature rise of more than 0.5°C. After drug administration, rectal temperature was recorded periodically at 1, 2, 3 and 4 hr. Furthermore, antioxidant activity was tested using the DPPH method.

    Results

    The results showed that administration of COI, AMI, AMCI, AAI, CPI, TII, ZOI, API, MCI and SCI was able to significantly reduce the rectal temperature of febrile rat which depended on dose and time. The antioxidant test results indicated that AAI exhibited very strong antioxidant intensity, while AMCI, CPI, ZOI, API and SCI showed strong antioxidant intensity, COI and MCI had medium antioxidant intensity, AMI had weak antioxidant intensity and TII displayed very weak antioxidant intensity.

    Conclusion

    Based on the results, it can be concluded that COI, AMI, AMCI, AAI, CPI, TII, ZOI, API, MCI and SCI exhibit antipyretic and antioxidant activity.

    Keywords: Antipyretic, Antioxidant, Medicinal plants, Peptone-induced rat model, DPPH

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