Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA
Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, SAUDI ARABIA
Health Research Center, Jazan University, Jazan, SAUDI ARABIA
Unit of Medical Microbiology, College of Applied Medical Sciences, Jazan University, Jazan, SAUDI ARABIA
Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA
Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA
Department of Pharmacology, Dr. Joseph Mar Thoma Institute of Pharmaceutical Sciences and Research, Alappuzha, INDIA
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ABSTRACT
Background
This study evaluated the chemical composition, antioxidant activity and antibacterial properties of methanol extracts of Ocimum basilicum L. leaves that were gathered from the Kingdom of Saudi Arabia’s Jazan province.
Materials and Methods
The extract was examined using FTIR and GC-MS techniques, which revealed the presence of terpenes (53.14%), Linalool (24.5%), sulfoxides (4.19%), cinnamic acid (5.23%), fatty acid esters (1.45%) and phthalic acid esters (0.72%).
Results
The extract contained significant levels of total phenolic compounds and demonstrated a DPPH radical scavenging capacity of 33.70%, which is considered to be good. The antibacterial activity spectrum of O. basilicum leaves’ methanolic extract was found to be broader. The extract was tested against eight different bacteria strains, including S. cholestasis, S. aureus, S. epidermidis, K. pneumoniae, E. coli, P. mirabilis, E. faecalis, and S. cholestasis.
Conclusion
With an inhibition zone of 21 mm, S. aureus exhibited the highest level of antibacterial activity, whereas P. aeruginosa demonstrated the lowest value, with an inhibition zone of 15 mm. Nonetheless, the activity range was more constrained than that of regular ciprofloxacin discs.