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Published on:November 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4s):s548-s553
Original Article | doi:10.5530/ijper.53.4s.149

Formulation and Development of Famotidine Solid Dispersion Tablets for their Solubility Enhancement


Authors and affiliation (s):

Shirsath Nitin Rajendra1,*, Jagtap Vaibhavkumar2, Goswami Ajaygiri Kamalgiri1

1University Institute of Chemical Technology (UICT), Kavayitri Bahinabai Chaudhari North Maharashtra University (KBCNMU), Jalgaon, Maharashtra, INDIA.

2A.R. Ajmera College of Pharmacy, Nagaon, Dhule, Maharashtra, INDIA.

Abstract:

Background: Famotidine is BCS class II drug having a low aqueous solubility and low oral bioavailability. It needs to develop into its novel form for solubility and dissolution rate enhancement. Materials and Methods: The aim of the current work was to formulate famotidine (FAM)-poloxamer 188 solid dispersions (SDs) by kneading method for solubility enhancement. The problems of low solubility were eliminated by preparing the SDs using the poloxamer 188 as hydrophilic carrier. Results and Conclusion: The prepared tablets of SDs were characterized by employing solubility, FTIR, disintegration test, friability, wetting time and in-vitro drug release. The optimum values of solubility and in-vitro drug release of prepared novel formulation were maximum than conventional dosage form. The famotidine (FAM)-poloxamer 188 solid dispersions were successfully prepared and seem to be promising for enhanced dissolution rate (solubility) and oral bioavailability.

Key words: Solid dispersions (SDs), Kneading method, Famotidine, Solubility, Dissolution rate, Bioavailability

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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