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Published on:March 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(2):329-336
Original Article | doi:10.5530/ijper.54.2.38

QbD Based Optimization of Curcumin Nanoemulsion: DoE and Cytotoxicity Studies


Authors and affiliation (s):

Shambhavi Dhananjay Acharya1, Preeti Kaustubh Tamane2, Shyam Nagarao Khante1, Varsha Babu Pokharkar3,*

1Department of Quality Assurance Techniques, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Erandwane, Maharashtra, INDIA.

2Department of Drug Regulatory Affairs, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Erandwane, Pune, Maharashtra, INDIA.

3Department of Pharmaceutics, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Erandwane, Pune, Maharashtra, INDIA.

Abstract:

Aim: The aim of this study was to employ a Quality by design (QbD) based approach for the development and optimization of stable curcumin (CUR) nanoemulsion (NE). Materials and Methods: The NE was developed using Tween 80 as surfactant, Tocopheryl polyethylene glycol 1000 succinate (TPGS) as cosurfactant and Kollisolv MCT 70 as oil phase. The Design of Experiment (DoE) consisted of a 3 level- 2 factor full factorial design for the optimization. The independent variables were concentration of surfactant mix (Smix) and oil phase while particle size, zeta potential and polydispersity index (PDI) were the dependent variables. The NE was evaluated for particle size, zeta potential, pH, viscosity, transmittance, drug content, in-vitro drug release, stability and in vitro anticancer activity. Results: The optimized formulation showed approximate particle size of 17nm, zeta potential -12.8 and polydispersity index 0.161 and was stable for three months at room temperature. The nanoemulsion showed better activity as compared to pure drug against pituitary and colon cancer cell-lines. Conclusion: QbD based approach can aid in the development of robust and thermodynamically stable NEs.

Key words: Nanoemulsion, QbD, Curcumin, Full factorial design, DoE.

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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