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Published on:May 2020
Asian Journal of Pharmaceutical and Health Sciences, 2020; 54(2s):s251-s260
Original Article | doi:10.5530/ijper.54.2s.81

In-vitro Anthelmintic Impact of Various Extracts of Pavetta tomentosa Root on Pheretima posthuma and in-silico Molecular Docking Evaluation of some Isolated Phytoconstituents


Authors and affiliation (s):

Dintakurthi Sree Naga Bala Krishna Prasanth1, Siva Prasad Panda2, Atmakuri Lakshmana Rao3, Nayudu Teja4, Veenam Bhavya Naga Vani3, Tera Sandhya5, Pathange Bharghava Bhushan Rao4

1Pharmacognosy Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA.

2Pharmacology Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA

3Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Krishna, Andhra Pradesh, INDIA.

4Department of Pharmaceutics, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Krishna, Andhra Pradesh, INDIA.

5Department of Pharmacology, Sri Padmavathi School of pharmacy, Tirupati, Andhra Pradesh, INDIA.

Abstract:

Background: The current study assesses the anthelmintic impact of root extracts of Pavetta tomentosa on Pheretima posthuma compiled by molecular docking analysis of phytocompounds steemed from the plant with the β-Tubulin (PDB ID: 1SA0). Methods: In this study, P. tomentosa root was subjected to extraction using methanol and water. In vitro, anthelmintic activity was assessed by utilizing the Pheretima posthuma and in silico molecular docking was executed making use of Autodock 4.0. Results: The outcomes revealed that the methanolic extract has the most significant dose-dependent anthelmintic activity at various doses, followed by aqueous extracts of root. Amongst all the substances, β-eudesmol revealed the most effective docking rating of -6.53, which is nearer to Albendazole, i.e., -6.79, ensuring that β-eudesmol has a strong binding fondness in between protein and ligand. Conclusion: From the examinations, a conclusion can be drawn that the anthelmintic activity of P. tomentosa root in both in vitro and insilico assays. The information sustains β-eudesmol to be a useful anthelmintic compound beneficial to future clinical examinations.

Key words: In-silico, Autodock 4.0, Pavetta tomentosa, β-eudesmol, Albendazole, ADME/T.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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