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Published on:July 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(3):xx-xx
Original Article | doi:10.5530/ijper.54.x.x

New Naphthyl Substituted Phytosterol and Lanostane Type-triterpenic Esters from the Stem Bark of Ficus religiosa L.


Authors and affiliation (s):

Abuzer Ali1, Mohammad Jameel2, Mohammed Ali3,*

1College of Pharmacy, Taif University, Taif, Al-Haweiah, SAUDI ARABIA.

2Regional Research Institute of Unani Medicine, Central Council of Research Unani Medicine, Aligarh, INDIA.

3Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, INDIA.

Abstract:

Background: Ficus religiosa L. (Moraceae) is considered as a holy tree in most of the part of south-eastern Asia. Traditionally, its bark is used in the treatment of burns, diarrhoea, dysentery, gastrohelcosis and gonorrhoea, glandular swellings of the neck, scabies, piles, urogenital disorders, anxiety, vomiting, skin diseases and prescribed to improve the skin complexion. Materials and Methods: The methanol extract of stem bark of F. religiosa was obtained by continuous hot extraction process. Isolation of phytoconstituents was done by silica gel column chromatography. Analytical thin layer chromatography was used to check the homogeneity of eluted fractions. The structures of isolated compounds were established on the basis of 1D and 2D NMR, FT-IR, UV and MS data and chemical means. Results: Phytochemical investigation of the methanol extract of F. religiosa stem bark led to the isolation of a new naphthyl substituted phytosterol characterized as naphthyl-1ʹ,3ʹ-diol-1ʹ-3β-sitosteryl-3ʹ-linoleinate (1) and a new lanostane type-triterpenic ester elucidated as lanostan-19-oic acid-3β-olyl-oleate (2). Conclusion: The present work has enhanced the phytochemical profile of F. religiosa. Compound 1 and 2 have been isolated for the first time from this plant and might be used as chromatographic markers for the quality control analysis of its marketed herbal formulations.

Key words: Ficus religiosa, Stem bark, Phytosterol ester, Lanostanol ester, Isolation, characterization, β-sitosteryl naphthadiolyl linoleinate, Lanostanoic acid oleate.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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