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Published on:31 Dec 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(4):340-345
Original Article | doi:NILL

Antidiabetic Activity of Pandanus odoratissimus Root Extract


Authors and affiliation (s):

Sama Venkatesh*1, Kusuma R1, Sateesh V1, Madhava Reddy B1 and Ramesh Mullangi2
1G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad - 500 028, India.
2Jubilant Innovation, 96, Industrial Suburb, Yeshwanthpur, Bangalore-566 022, India

Abstract:

The aqueous ethanolic extract of Pandanus odoratissimus (Pandanaceae) root was tested for its effect on blood glucose levels in normal and diabetic rats. Hypoglycemia was observed in basal conditions when tested at an oral dose of 75, 150 and 300 mg/kg body weight. The ethanolic extract has displayed a significant dose-dependent antihyperglycemic activity in oral glucose tolerance test and also found to reduce the increased blood glucose in alloxan-induced diabetic rats (37% at 150 mg/kg and 51% at 300 mg/kg body weight). Chronic administration (10 days) of the ethanolic extract of root significantly reduced the blood glucose in alloxan-induced diabetic rats. The extract was also found to reduce the increased blood urea, inhibit the body weight reduction and leucopenia induced by alloxan administration. The ethanolic extract was found to effectively scavenge the DPPH and lipid peroxide free radicals in vitro with an IC value of 50 10 and 8 μg/ml, respectively. The preliminary phytochemical examination reveals the presence of flavanoids and tannins, which may be attributed to observed antioxidant and significant antihyperglycemic properties.

Keywords: Pandanus odoratissimus, alloxan, glucose tolerance, diabetes, roots, antihyperglycemia, antioxidant activity.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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