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Published on:December 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(4):1153-1158
Original Article | doi:10.5530/ijper.54.4.211

New Method for the in vivo Estimation of Fluvastatin and its Application for Pharmacokinetic Studies in Rabbit

Authors and affiliation (s):

Deepthi Sandhala*, Srinivas Lankalapalli

GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, Andhra Pradesh, INDIA.


Aim: The study was aimed to conduct a pharmacokinetic evaluation of Fluvastatin in rabbit plasma using a sensitive HPLC method. Materials and Methods: The plasma samples were assayed by Waters alliance e-2695 HPLC instrument using symmetry C18 column (150x4.6mm, 3.5 μ) under isocratic condition. Here the buffer was 0.1% ortho phosphoric acid. Mobile phase used was acetonitrile and 0.1% ortho phosphoric acid in 50:50 v/v with a flow rate of 1 ml/min. The eluent was monitored at 224 nm for measurement of Fluvastatin. Results: The calibration curve was linear over the concentration range of 5-200 ng/ml of Fuvastatin. Conclusion: The application denotes all the parameters of system suitability, specificity, linearity and accuracy are in good agreement with USFDA guidelines and applied effectively for the investigation of pharmacokinetic studies in rabbit.

Key words: RP-HPLC, Fluvastatin, Rabbit Plasma, Linearity, Accuracy, Pharmacokinetics.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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