Home | Articles
Published on:31 Dec 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(4):296-302
Original Article | doi:NILL

Preparation and Evaluation of Freeze Dried Crystals of Ketoprofen using Lyophilization Monophase Solution Technique for Direct Compression Tablets


Authors and affiliation (s):

Mudit Dixit*, Parthasarthi K Kulkarni and Panner Selvam
Department of Pharmaceutics, J.S.S College of pharmacy, J.S.S University, Mysore - 570015, Karnataka, India.

Abstract:

Ketoprofen, an anti-inflammatory drug, exhibits poor water solubility, dissolution and flow properties. Thus, the aim of the present study was to improve the solubility and dissolution rate of Ketoprofen by preparing crystals by freeze drying technique. Ketoprofen crystals were prepared by freeze drying using Isopropyl alcohol (IPA), chloroform and water as monophasic solvents system to enhance solubility and dissolution rate. The prepared crystals of Ketoprofen were evaluated for IPA and chloroform solvent residual by gas chromatography. The prepared formulations were characterized by scanning electron microscopy, differential scanning calorimeter; X-ray diffraction and Fourier transform infrared spectroscopy. Solubility and Dissolution profile of the freeze dried crystals was compared with its recrystallized sample and pure sample. The samples were stored in stability chamber to investigate their physical stability. Solvent residual of IPA and chloroform were found to be within the toxic level in prepared freeze dried crystals. Freeze dried crystals exhibited decreased crystallinity, the solubility of freeze dried crystals increasing nearly about fivefold than the ketoprofen pure sample. Dissolution of the ketoprofen crystals was significantly improved about three times higher than pure sample of ketoprofen. In stability test, the release profile of the freeze dried crystals was almost unchanged as compared with the freshly prepared freeze dried crystals stored at 40 0C and 75% relative humidity for 90 days. The dissolution profiles of ketoprofen tablets prepared using freeze dried crystals exhibit greater dissolution behavior than tablets prepared by pure ketoprofen sample. Hence this technique can be used for formulation of tablets of ketoprofen by direct compression with directly compressible tablet excipients. Keywords: Ketoprofen, Freeze drying, compressibility, Solubility, Dissolution, Stability.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
7 + 2 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.




 

User login

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
2 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs