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Published on:November 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(4):xx-xx
Original Article | doi:10.5530/ijper.54.4s.x

Evaluation of Gelling Behavior of Natural Gums and their Formulation Prospects


Authors and affiliation (s):

Rachit Mohan1, Shobha Singh2, Geetendra Kumar1, Manjoosha Srivastava2,*

1Phytochemistry Division, CSIR-National Botanical Research Institute, Lucknow, Uttar Pradesh, INDIA.

2Academy of Scientific and Innovative Research (AcSIR), Kamla Nehru Nagar Ghaziabad, Uttar Pradesh, INDIA.

Abstract:

Purpose: Gums and polymers can be found abundantly in the nature from various plants, microbial and marine sources. Their physical and functional characteristics can be customized according to its application in product development. The purpose of this study is to determine the potentiality of natural gums obtained from plant based sources in development of gel formulation and its comparison with the commercially used polymers viz. Carbapol 934, Carboxy Methyl Cellulose, Xanthan, Sodium Alginate. Methods: Gel formulations of varying ranges of polymeric concentrations were prepared and evaluated for its pharmaceutical parameters like pH, viscosity, homogeneity, tensile strength and antimicrobial activity. Results: The analysis of the developed gel formulations indicated that formulations developed using Guar gum possess much better gelling behavior i.e. viscosity and muco-adhesiveness then other selected gums and is more closer to its synthetic counterpart like Carbopol 934 and Sodium alginate. Thus natural gum provides a comparatively broader range of characteristics and eco-friendly approach which enhances its applicability in formulation development. This research work rationalizes the importance of natural gums as gelling agents in development of pharmaceutical dosage forms, cosmetic products and nutraceutical formulations.

Key words: Eco-friendly, Gelling agents, Gel Formulations, Muco-adhesiveness, Antimicrobial activity.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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