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Published on:February 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(1):86-94
Original Article | doi:10.5530/ijper.55.1.12

Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole


Authors and affiliation (s):

Vedanshu Malviya

Department of Pharmaceutics, PR Pote Patil College of Pharmacy, Amravati, Maharashtra, INDIA.

Abstract:

Purpose: The main objective of present study is to evaluate the effect of various factors which have direct influence on the characteristic parameters of emulsomes formulation, so that optimized combination of factors can be find out which meet the high level of set desirability criteria. The present work is focused on the optimization of emulsomes formulation by applying Box-Behnken design (BBD) of experiment. Emulsomes are the modified form of emulsomes which consists of solid lipid core surrounded by phospholipid bilayer. Methods: Emulsomes were prepared by lipid film hydration method using Phosphatidylcholine (PHL), Tristearin (TRI), Stearylamine (STR), Cholesterol (CHOL) and Bifonazole as drug candidate. Formulations were optimized by using three factor three levels Box-Behnken (BBD) design of experiment. BBD was applied considering 3 factors as independent variables viz. Phospholipid ratio to Drug (A), Phospholipid to Tristearin ratio (B) and Phospholipid ratio to Stearylamine (C) at 3 levels (-1, 0, +1) to study their effect on dependent variables viz. Particle size (Y1), Zeta Potential (Y2) and Entrapment efficiency (Y3). Results of independent variables (A, B, C) were analysed to construct quadratic equation and 3-D response surface curves for each dependent variable (Y1, Y2, Y3). Results: The optimized formulation was selected on the basis of desirability criteria of minimum particle size, maximum zeta potential and maximum entrapment efficiency. The final optimized formulation has predicted particle size (390.394 nm), zeta potential (45.0mV) and entrapment efficiency (81.642%). Conclusion: BBD is remarkable design of experiment for studying the effect of 3-factors at 3-levels on the responses in optimizing the emulsomes formulation.

Key words: Box-Behnken Design (BBD), Emulsomes, Bifonazole, Phospholipid, Stearylamine, Tristearin.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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