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Published on:31 Mar 2013
Indian Journal of Pharmaceutical Education and Research, 2013; 47(1):82-89
Original Article | doi:

Anti-Psoriatic Activity of Smilax china Linn. Rhizome


Authors and affiliation (s):

Vijayalakshmi. A*, Ravichandiran. V, Malarkodi Velraj, Nirmala. S, Anusha Male, Jayakumari. S and
Masilamani. K
Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels University, Chennai, India.

Abstract:

Objectives: The rhizome of the plant Smilax china Linn. has been used in Siddha and Ayurveda in the treatment of Psoriasis and various skin diseases. In the present study, the methanolic extract and ethyl acetate fraction of Smilax china Linn. rhizome was evaluated for antipsoriatic activity. Methods: Mouse tail test was used for the evaluation of antipsoriatic activity. The methanolic extract and ethyl acetate fraction at a dose of 100 and 200 mg/kg b.w. were evaluated for antipsoriatic activity in Swiss albino mice using mouse tail test. The parameter studied in the mouse tail test was percentage orthokeratotic values. In vitro antiproliferant assay on HaCaT cell lines and determination of serum nitric oxide levels were also carried out. Result and conclusion: The ethyl acetate fraction of Smilax china rhizome (200 mg/kg) showed maximum antipsoriatic activity (increased orthokeratotic region by 29%) when compared with methanol extract.

Keywords: Smilax china, Anti-psoriatic, ethyl acetate fraction, Quercetin, HaCaT cells.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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