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Published on:December 2015
Indian Journal of Pharmaceutical Education and Research, 2016; 50(2s):S159-S167
Original Article | doi:10.5530/ijper.50.2.32

Natural Gellan Gum (Phytagel®) Based Novel Hydrogel Beads of Rifampicin for Oral Delivery with Improved Functionality


Authors and affiliation (s):

Jagadevappa Shrimanthrao Patil1, Sachin Manik Jadhav2, Satish Vasant Mandave2, Kailash Vishwanath Vilegave1, Shivsharan Basavraj Dhadde3

1Department of Pharmaceutics, VT’s, Shivajirao.S. Jondhle College of Pharmacy, Asangaon-421 601, Maharashtra, INDIA.

2Department of Pharmaceutics, SVERI’s College of Pharmacy, Pandharpur-413304, Maharashtra, INDIA.

3Department of Pharmacology, VT’s, Shivajirao.S. Jondhle College of Pharmacy, Asangaon-421 601, Maharashtra, INDIA.

Abstract:

Background:Despite exhaustive global efforts, tuberculosis (TB) continues to higher rates ofinfection and drug-resistance rates are also raising to alarming levels. Sustained release dosage forms are gaining higher acceptance over conventional dosageforms in the treatment of several chronic conditions including TB. The aim of this study was to investigate whether the novel particulate system improved the drug release profile of rifampicin when formulated with natural polymer based hydrogel beads along with betacyclodextrin as a solubility enhancer. Materials and Methods: Particulate hydrogel beads were prepared by ionotropic gelation method using divalent calcium cations. Prepared beads were coated with chitosan through polyelectrolyte complexation. Formulations were evaluated for drug content, particle size, swelling index and in-vitro dissolution, and further characterized by Scanning Electron Microscopy, Fourier Transfer Infrared Spectroscopy, Differential Scanning Calorimerty and X-Ray Diffractometry. Results: All the formulations showed sustained drug release but the formulations G2 exhibited highest amount of drug release among all. While considering the formulations with cyclodextrin the release rate is slightly increased at initial hours. The formulations with chitosan coating showed sustained release up to 24 h.Conclusion:Utilization of natural polymers was proved to be effective in formulating a novelparticulate sustained release solid dosage form of rifampicin and presence ofcyclodextrinproved to be useful in solubility enhancement which can achieve higher drug release.

Keywords: Microbeads, Hydrogels,Tuberculosis, Lonotropic gelation, Chitosan.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs