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Published on:July 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(3s):s180-s184
Research Article | doi:10.5530/ijper.51.3s.8

Anti-Inflammatory Effects of Essential Oils from Rosmarinus officinalis and Populus alba on Experimental Models of Acute and Chronic Inflammation in Rats


Authors and affiliation (s):

Hamza Belkhodja1, Boumediene Meddah1, Sevgi Gezici2

1Department of Biology, University of Mascara, ALGERIA

2Department of Biology, Molecular Biology, University of Gaziantep, TURKEY

Abstract:

Objective / Purpose: Essential oils (EOs) distelled form aromatic plants have a wide range of uses because of their rich pharmacological activities including, antiinflammatory, antitumor, antimicrobial, antioxidant, antidiabetic and hepatoprotective. The present research aimed to investigate in-vivo anti-inflammatory effects of EOs from Rosmarinus officinalis and Populus alba as biomarker levels in well-defined acute and chronic inflammation models. Material and Methods: The anti-inflammatory activity of EOs of R. officinalis and P. alba was carried out using two model, one of them is acute inflammation that induction by dextran 1% at the rat paw1 and another is chronic inflammation that induction by monoiodoacetic solution.2 To evaluate the anti-inflammatory properties of EOs, a measure of paw thickness was carried out with the calculation of percent inhibition. Thus, monitoring of some biomarkers will be paramount. Results / Discussion: The results indicate the absence of severe clinical signs or dead in rats during the observation period. Therefore, the EOs of R. officinalis and P. alba are devoid of acute toxicity in rats. For treatment with the EOs of R. officinalis, P. alba and Diclofenac®, the results showed a significant reduction for responses induced by dextran. Treatments produced reductions in inflammation ranging from 2.19 to 15.15%. Treatment with EOs showed a recovery of values of biochemical markers during the experimental period. Conclusion: The EOs of R. officinalis and P. alba demonstrate anti-inflammatory effect on both acute and chronic inflammation models, thus they could be used for pharmacological purposes as anti-inflammatory agents.

Key words: Anti-inflammatory, Essential oils, Experimental model, Rosmarinus officinalis, Populus alba.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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