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Published on:January 2018
Indian Journal of Pharmaceutical Education and Research, 2018; 52(2):212-217
Original Article | doi:10.5530/ijper.52.2.24

Technological and Biopharmaceutical Characterization of Carbopol-Based Ketoprofen Emulgels


Authors and affiliation (s):

Petya Peneva1*, Velichka Andonova1, Teodora Dimcheva2, Margarita Kassarova1

1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University-Plovdiv, 15A Vassil Aprilov Blvd, Plovdiv 4002, BULGARIA.

2Department of Medical Informatics, Biostatistics and E-learning, Faculty of Public Health, Medical University-Plovdiv, 15A Vassil Aprilov Blvd, Plovdiv 4002, BULGARIA.

Abstract:

Objective: Emulgels are a combination of emulsions and gels. In this study, the influence of different oil phases and gelling agent concentrations on the technological and biopharmaceutical characteristics of prepared emulgels is assessed. Materials and Methods: Light liquid paraffin (various concentrations), cetyl alcohol, isopropyl myristate, and almond oil were used in the oil phase of the emulsions, and Carbopol® 940 (0.5%, 0.75%, and 1% w/w concentrations) was used as the gelling agent for the gel base. The prepared emulgels were characterized in terms of pH, rheological behavior, spreadability, and in vitro release of ketoprofen. Results and Discussion: All formulations produced stable, white, semisolid forms with smooth homogeneous textures and no phase separations. The pH of the resulting emulgels ranged from 5.5 to 6.5. An increase in the carbopol concentration led to an increase in viscosity, and all prepared emulgels exhibited pseudoplastic flow. The spreadability of semisolid dosage forms improved by reducing the concentration of the gelling agent. Results from the in vitro study indicated that 88.48%-99.11% of the ketoprofen was released within 150 min. Conclusion: The prepared emulgels are in semisolid form, and hence suitable for topical application.

Key words: Carbopol, Emulgels, Ketoprofen, Topical application.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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