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Published on:June 2018
Indian Journal of Pharmaceutical Education and Research, 2018; 52(3):398-407
Original Article | doi:10.5530/ijper.52.3.46

Formulation and Evaluation of Oral Fast Dissolving Films of Poorly Soluble Drug Ezetimibe Using Transcutol Hp


Authors and affiliation (s):

Pondugula Sudhakara Reddy1, KV Ramana Murthy2*

1Star “A” apartments, Bhagyanagar colony, Kukatpally, Hyderabad, Telangana 500072, INDIA.

2Professor of Pharmaceutics, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, Andhra Pradesh, INDIA.

Abstract:

Introduction: The objective of the present formulation research is to deliver the drugs at a faster rate and to provide immediate onset of action in a shorter period of time with improved bioavailability. Materials and Methods: Ezetimibe, a gift sample from Lupin Ltd., Pune, Transcutol HP, a gift sample from Gattefosse India Pvt. Ltd., Goa., HPMC E5, HPMC E6, HPMC E15 are gift samples from Colorcon India Pvt. Ltd. Results and Discussion: Among prepared formulations coded E1 to E20, formulation E6 was shown promising results, hence further studies done without transcutol HP and documented clear results saying that, without transcutol HP has shown around 50% of drug even after 90 min of time, whereas within 10 min complete drug release observed with transcutol HP formulation. Conclusion: The study clearly indicated the influence of transcutol HP in enhancing the solubility of the poorly soluble drugs as the films made without transcutol HP failed to give the desired release characteristics within 10 min.

Key words: Ezetimibe, Transcutol HP, HPMC E5, HPMC E6, HPMC E15, Pectin.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs