Home | Articles
Published on:Jul 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(3):235-242
Original Article | doi:NILL

Carbopol and Sodium Carboxymethylcellulose Based Methylsulfonylmethane Gels for Treatment of Osteoarthritis: In-vitro and In-vivo Evaluation


Authors and affiliation (s):

Vishwajeet Ghorpade*, Kailas Mali, Remeth Dias and Prashant Karande

Satara College of Pharmacy, Behind Spicer India Ltd., Degaon, Satara, Maharashtra, India, 415004.

Abstract:

The objective of present study was to prepare transdermal gels of methylsulfonylmethane (MSM) alone or in combination with aloe vera and sesame oil using polymers like carbopol 940 (CP) and sodium carboxymethylcellulose (NaCMC). The physicochemical compatibility of drug and the polymers was confirmed by infrared spectroscopy and differential scanning calorimetry. The gels were evaluated for various physicochemical parameters such as pH, homogeneity, spreadability, viscosity measurement and drug content. In-vitro drug release study across cellophane membrane was performed. CP based gels (F1- F4) showed higher drug release ranging from 89.7% to 96.4% than NaCMC based gels (F5- F8) with drug release ranging from 79.5% to 89.1% at the end of study. Also, CP based gels showed more prominent anti-inflammatory activity (69.25 to 81.5% inhibition) than NaCMC based gels (54.4 to 72.3 % inhibition). CP based F4 formulation was considered to be optimized formulation based on its in vitro drug release and anti-inflammatory activity studies. The F4 formulation was further subjected to skin irritation study, short term stability study and In-vivo study on osteoarthritic patients. It was observed that Lequesne's score was significantly reduced (p<0.05) as compared to placebo, demonstrating that patient's symptoms can be improved with MSM gel containing aloe vera and sesame oil. However, further clinical studies on larger number of patients are required. From the results obtained, it can be concluded that the MSM gel containing aloe vera and sesame oil can be better alternative for treating the patients with osteoarthritis.

Keywords: Methylsulfonylmethane, Transdermal gel, Osteoarthritis, Aloe vera, Sesame oil.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
5 + 1 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.




 

User login

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
2 + 17 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs