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Published on:Jul 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(3):265-269
Original Article | doi:NILL

Design and In-vitro Characterization of Levobunolol Hydrochloride Occuserts with Special Reference to Glaucoma Treatment


Authors and affiliation (s):

Ashish Pandey*1, Prashant Y. Mali2, Dinesh Sachdeva3 and Ravada Ramesh4

1Department of Pharmaceutical Sciences (FAMS), Gurukul Kangri University, Haridwar - 249404, Uttarakhand, India

2Department of Biomedical Sciences, School of Health and Hospital,Adama Science and Technology University, Asella Medical Campus, P.O. Box – 396, Oromia, Ethiopia

3Registrar, Rajasthan State Pharmacy Council, Jaipur - 302006, Rajasthan, India

4Dr. H. L. T. College of Pharmacy, Kengal, Channapatna - 571502, Bangalore (Rural), Karnataka, India

Abstract:

The aim of present study was to design and in-vitro characterization of Levobunolol HCl occuserts with special reference to glaucoma treatment. Levobunolol HCl ophthalmic solution has been shown to be effective in IOP and may be used in patients with chronic open-angle glaucoma or ocular hypertension. The Levobunolol HCl occuserts were prepared using hydroxypropyl methylcellulose (HPMC, 3 & 4%), poly vinyl pyrrolidone (PVP, 1%), methyl cellulose (MC, 1 & 2%) as polymers by solvent casting technique with objectives of increasing contact time, achieving controlled release, reduction in frequency of administration and greater therapeutic efficacy. The prepared occuserts were then evaluated for there physical appearance and surface texture, weight variation, uniformity of thickness, tensile strength and % elongation at break, % moisture uptake, % moisture loss, folding endurance, drug content and in-vitro drug release. It is evident from these studies that, formed polymeric occuserts have appreciable strength and safety. Physiochemical characterization and in-vitro drug release studies reveals that, the prepared occusert formulations (F & F ) containing 4 % and 3 % HPMC had released their drug content, 83 % and 81 % respectively 2 1 over an extended period of 12 hr. Hence, these formulations were selected as best optimized formulations.

Keywords: Levobunolol HCl, Occusert, Glaucoma, In-vitro characterization

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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