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Published on:March 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(2):385-396
Original Article | doi:10.5530/ijper.54.2.44

In vitro Evaluations of Biodegradable Polyacrylamide Grafted Moringa Bark Gum Graft Copolymer (MOG-g- PAAM) as Biomedical and Controlled Drug Delivery Device Synthesized by Microwave Accelerated free Radical Synthesis


Authors and affiliation (s):

Nikhil Rai, Trishna Bal*, Sabyasachi Swain

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, INDIA.

Abstract:

Aim: The present work is based on preparation of different grades of Moringa Bark Gum (MOG) with Acrylamide (AM) with varying amount of AM (monomer) and APS (redox initiator) using microwave accelerated free radical reaction. Objectives: In the current work, the Moringa bark gum grafted with acrylamide graft copolymer was tested for tissue engineered polymeric scaffold as well as controlled drug delivery system using metronidazole as a model drug. Methodology: The microwave radiation process was used along with redox initiator for the graft copolymerization process and the optimization of the grades was done using % grafting efficiency, intrinsic viscosity. Moreover, the optimized grade GF4 was analyzed with FTIR as well as NMR proving efficient grafting has resulted along with TGA, OCA and XRD. Results: The grade GF4 showed 95% drug release for 24 hours with only 1% hemolysis proving non-toxic and SEM images evidence its biodegradability thereby making the grade GF4 suitable for controlled release as well as tissue engineered scaffold. Conclusion: The results indicated that the optimized grade GF4 can be utilized as biodegradable polymer having applications in controlled delivery of drugs as well as scaffold for cell proliferation in wound healing and burn therapies.

Key words: Graft Copolymer, Metronidazole, Moringa Gum, Microwave Irradiation, Biodegradability, Controlled drug release, Polymeric scaffold, Histopathology.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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