Home | Articles
Published on:December 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(4):971-982
Original Article | doi:10.5530/ijper.54.4.191

Formulation and Evaluation of Phanera variegata Linn. Mucilage as a Pharmaceutical Binder in Solid Dosage Form


Authors and affiliation (s):

Keshav Bansal, Meenakshi Bajpai*

Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, INDIA.

Abstract:

Objectives: The present study is aimed to isolate, evaluate the mucilage obtained from the leaves of Kachnar (Phanera variegata) and to compare the binding efficacy of the isolated mucilage with acacia gum. Methods: Extraction and isolation of mucilages from the leaves of Phanera variegata were carried out by the maceration method. The isolated mucilage was analyzed for phytochemical, microbial andvarious physico-chemical properties for acceptability as a novel excipient for the formulation of tablets. Uncoated paracetamol tablets of different batches (F1–F4) were prepared by preparing granules (different concentrations) of isolated mucilage (3%, 5%, 10% and 15% w/v respectively) using wet granulation technique.The formulated tablets were evaluated: pre-compression (Micromeritics properties) and post-compression parameters (size, hardness, friability, weight uniformity, content uniformity, disintegration and in vitro dissolution profile.) For comparison purposes, acacia gum was used as a binder and different batches of tablets (A1 – A4) were prepared similarly and evaluated for pre-compression and postcompression parameters. Results: The formulated tablets using isolated mucilage had a good appearance, on increasing the concentration of binder hardness of tablets were also increased, all the formulations fall within the limit for friability and disintegration according to official standards, in vitro dissolution profile of optimized formulation F2 showed 98.28% drug release within 20 min. Conclusion: According to the observation, isolated mucilage can opt as an alternative natural excipient (binding agent) for the formulation of uncoated tablets. Phanera variegata is a novel plant with less or almost no reported data.

Key words: Paracetamol, Phanera variegata, Mucilage, Maceration, Formulation, in vitro dissolution.

 




 

Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs