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Published on:October 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(3s):s610-s619
Original Article | doi:10.5530/ijper.54.3s.161

Synthesis and QSAR Studies of Novel Pyrazoline Derivatives as Antiproliferative Agent


Authors and affiliation (s):

Prafulla Madhukarrao Sable*, Nusrat Bhuru Ali Sayyad

Department of Pharmaceutical Sciences Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, INDIA.

Abstract:

Background: Regardless of recent advances in the biological processes leading to the development of cancer, there is still a need for new and effective agents to help bring this disease under control. The revelation of the anticancer properties of pyrazoline makes this scaffold remarkable for research and development as an anticancer. Methods: A series of synthetic chalcones and pyrazoline derivatives were synthesized, characterized IR, 1H NMR and mass spectral analysis and evaluated for their Anticancer activity on MCF-7 cell line through SRB assay. A QSAR study was performed on thirtyfive compounds of known series having pyrazoline nucleus using Accelrys Discovery Studio Vs 2.1.0.8130. Results: We found that significant inhibitory activity among all the synthesized compound 1B showing better anticancer activity having IC50 value 0.010 μM as compared to standard drug letrozole. So predicted molecules from the QSAR study show significant activity. Conclusion: We would conclude that compound 1B might serve as a potential antiproliferative agent.

Key words: Pyrazoline, QSAR, SRB assay, MCF-7, Antiproliferative activity.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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