Home | Articles
Published on:31 Dec 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(4):318-322
Original Article | doi:NILL

Design and Evaluation of Fast Dissolving Films Containing Nizatidine


Authors and affiliation (s):

Nagaraju R1, Sujatha B1, Vidyadhara S2 and Sasidhar RLC2 *
1Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam, (Women's University) Tirupati, A.P
2 Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, A.P.

Abstract:

The present study deals with the formulation of fast dissolving films of nizatidine as a model drug which is used for the treatment of acid-reflux disorders, peptic ulcer disease, and active duodenal ulcer. Rapidly dissolving dosage forms have acquired great importance in pharmaceutical industry because of their unique properties. In the present research work various trails were carried out using maltodextrin and the concentration of excipients were optimized to prepare an ideal film for drug loading. Casting method was used for the preparation of films. The prepared films were evaluated for film thickness, folding endurance, disintegration time, dissolution time and for drug content. The in vitro dissolution studies were carried out in three media, distilled water, simulated gastric fluid ( pH 1.2 ) and simulated salivary fluid ( pH 6.8 ). The prepared films were found to be uniform, flexible, more than 90 % of the drug was found to be released from the film with in 4 min which is a desirable characteristic for fast absorption. FT IR and DSC studies were carried out to study drug excipient interactions. From these studies it is observed that there was no interaction between drug and excipients used and the drug is stable in the formulation. The in vivo disintegration time and taste evaluation studies were carried out in human volunteers after taking approval by the ethical committee, IPT, SPMVV(Sri padmavathi mahila Visva Vidyalayam). These results revealed that there was no bitter taste, no irritation and good mouth fell was observed. The in vivo disintegration time was in agreement with in vitro results. This confirms the successful formulation of nizatidine in the form of fast dissolving films.

Keywords : Fast dissolving Films, Nizatidine, Taste masking.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
3 + 11 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.




 

User login

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
2 + 1 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs