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Published on:30th Jan 2014
Indian Journal of Pharmaceutical Education and Research, 2014; 48(1):39-48
Pharmaceutical Research | doi:10.5530/ijper.48.1.7

The Chemopreventive Effect of Nigella Sativa on 1,2-dimethylhydrazine-induced Colon Tumor


Authors and affiliation (s):

Dadkhah Aa,*, Fatemi Fb, Malayeri Mc, Jahanbani Ad, Batebi Fe and Ghorbanpour Ze
aDepartment of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, Iran
bNuclear Fuel Cycle research school, Nuclear Science and Technology Research Institute, Tehran, I.R. Iran
cDepartment of pathobiology, Faculty of veterinary medicine, Garmsar Branch, Islamic Azad University, Garmsar-Iran
dYoung Researchers Club, Garmsar Branch, Islamic Azad University, Garmsar, Iran
eDepartment of Biochemistry, Faculty of Sciences, Payame-e-Noor University, Tehran, Iran

Abstract:

In this study, the chemopreventive efficacy of Nigella sativa seed powder as an important chemopreventive herb on the formation of colon tumor has been examined through measuring the levels of hepatic oxidative stress and metabolizing enzymes in 1,2-dimethylhydrazine (DMH)-induced colon cancer in rats. Male Wistar rats were divided into 6 groups as untreated control, Sham, DMH (30mg/kg b.w) received carcinogen via subcutaneously (s.c) injection once a week for 18 weeks and treatment groups received diet containing Nigella sativa (2 and 4%) until the end of whole experimental period of 6 months. It is indicated that Nigella sativa seed powder could prevent colon tumor formation by modulating the activities of hepatic detoxification enzymes, GST and CYP450 whereas antioxidant statues are not affected. The data was confirmed by histopathological findings It is obvious that one of the mechanisms of chemoprevention of colon tumorigenesis by Nigella sativa seed powder may be the enhancement of carcinogen detoxification but not antioxidant system in the liver.

Key words: Nigella sativa, Colon tumor, DMH, Antioxidant parameters, Xenobiotic metabolizing enzymes.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs