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Published on:25th May 2015
Indian Journal of Pharmaceutical Education and Research, 2015; 49(4s):s68-s74
Pharmaceutical Research | doi:10.5530/ijper.49.4s.8

Effect of the ethanolic extract of Scoparia dulcis in cisplatin induced nephrotoxicity in wistar rats


Authors and affiliation (s):

Smitha Jose1* and Sreedevi Adikay2

1Department of Pharmaceutical Chemistry, Visveswarapura Institute of Pharmaceutical Sciences, Benashankiri, Bangalore 560 080, Karnataka, India.(affiliated to R.G.U.HS)

2Department of Pharmaceutical Technology, Sri Padmavathy Mahila Visvavidyalayam University, Thirupati 517 502, Andra Pradesh, India. (affiliated to S.P.M.V.U.)

Abstract:

Objective: To evaluate the nephroprotective potential of ethanolic extract of aerial parts of plant Scoparia dulcis against cisplatin induced nephrotoxicity in Wistar rats. Materials and Methods: Nephrotoxicity was induced by a single intra-peritoneal administration of Cisplatin (6 mg/kg) in wistar rats. Nephroprotective potential of plant was tested at two different doses in curative regimen and for a single dose of 400 mg/kg in prophylactic control. Nephrotoxicity was characterised by induced marked renal failure, significant increase in blood urea nitrogen, serum creatinine level, lipid peroxidation levels and significant decrease in urinary creatinine clearance. Histopathological studies confirmed tubular necrosis. Supplementation of ethanolic extract of Scoparia dulcis reduced the elevated serum creatinine, blood urea nitrogen levels, lipid peroxidation levels and improved the creatinine clearance. Results and Discussion: Our experimental results suggest that supplementation of Scoparia dulcis during cisplatin therapy reduces the risk of cisplatin induced nephrotoxicity in a dose dependent manner in curative regimen. The prophylactic regimen also possessed significant nephroprotection against cisplatin toxicity. The protective effect of Scoparia dulsis in curative and prophylactic regimen may be due to the antioxidant property of Scoparia dulcis. These findings suggest the significant nephroprotection of Scoparia dulcis against cisplatin nephrotoxicity.

Key words: Nephrotoxicity, Scoparia dulcis, Cisplatin, lipid Peroxidation, anti-oxidant.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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