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Published on:August 2016
Indian Journal of Pharmaceutical Education and Research, 2016; 50(3):368-375
Original Article | doi:10.5530/ijper.50.3.8

Anthocyanin Improving Metabolic Disorders in Obese Mice from Aornia melanocarpa


Authors and affiliation (s):

Jie Wei1*, Guokun Zhang1, Xiao Zhang1, Jun Gao2, Jungang Fan2, Zhiquan Zhou2

1School of Life Science, Liaoning University, Shenyang 110036, CHINA.

2Foresty Science Research Institute of Liaoning Province, Shenyang, CHINA.

Abstract:

The aim of this study was to investigate the effects of Aornia melanocarpa anthocyanin (AMA) on symptoms of metabolic syndrome in obese mouse. AMA can reduce weight. Blood glucose and lipid metabolism were significantly improved, and so as hepatic lipid metabolism. This suggesting AMA is a strong indication of improved glucoselipid metabolism and weight. Moreover, both morphologic and histological detections indicated that AMA significantly reversed obsity induced hepatic steatosis and liver injury. Furthermore, AMA significantly ameliorated inflammatory cytokines including both IL-6 and TNF-α in liver and fatty tissue. Moreover, insulin receptor (IR), p-IRS and p-AKT that associated proteins about glucose-lipid metabolism signaling pathway were markedly up-regulated at protein levels by AMA. Our results demonstrate that Aornia melanocarpa anthocyanin treatment can alleviate obsity and metabolic syndrome. The beneficial effects of AMA are associated with improved glucose-lipid metabolism and reduced levels of inflammatory cytokines.

Key words: Metabolic disorders, Obese, Aornia melanocarpa, Anthocyanin, Mechnism.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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