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Published on:March 2017
Indian Journal of Pharmaceutical Education and Research, 2017; 51(2):321-328
Original Article | doi:10.5530/ijper.51.2.38

Anti-Hepatotoxic and Antioxidant Activity of Limnanthemum indicum Against Carbon Tetrachloride Induced Liver Toxicity in Rats


Authors and affiliation (s):

Jyothi Yachamaneni1*, Sangeetha Dhanraj2

1Department of Pharmacology, Krupanidhi college of Pharmacy, Bangalore-35, Karnataka, INDIA.

2School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, INDIA.

Abstract:

Objective: Whole plant of Limnanthemum indicum (Menyanthaceae) is traditionally used for liver disorders. Limnanthemum indicum was investigated for its Anti-hepatotoxic and Antioxidant activity. Materials and Methods: Alcoholic extract of whole plant of Limnanthemum indicum (100, 200, 400 mg/kg, p.o.) was evaluated for its Anti-hepatotoxic and Antioxidant activity in Carbon tetrachloride (CCl4)-induced liver toxicity in Rats. The Anti-hepatotoxic activity was assessed from biochemical and histopathological studies. Results:The administration of CCl4 in rats induced hepatotoxicity which was evidenced by increased levels of Aspartate aminotransferase Alanine aminotransferase, Alkaline phosphatase and total bilirubin and oxidative stress. Pretreatment with Limnanthemum indicum extract significantly protected the liver in Carbon tetrachloride administered rats. Limnanthemum indicum extract significantly elevated antioxidant enzymes like superoxide dismutase, catalase, glutathione, Glutathione peroxidase, Gamma glutamyl Transferase and Glutathione- S-Transferase and decreased lipid peroxidation levels in liver. Histological studies showed that Limnanthemum indicum at 400 mg/kg reduced the hepatocellular damage in CCl4 treated Rats. Conclusion: Thus the alcoholic extract of Limnanthemum indicum shows good antihepatoxic and antioxidant activity.

Key words: Carbon tetrachloride, Hepatoprotective, Limnanthemum indicum, Antioxidant, Alcohoic extract, Histopathology.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs