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Published on:February 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(2):236-241
Original Article | doi:10.5530/ijper.53.2.31

Pharmacokinetic Differences of Three Aconitum Alkaloids from Aconiti lateralis Radix Praeparata and Compatibility with Pinellia in Rats


Authors and affiliation (s):

WU Jian1,2*, LI Wen-lan1,2, XU Ying1,2, LIU Ying-jie1,2, LIU Ri-jia1,2, YU Miao1,2

1Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, CHINA.

2Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin 150076, CHINA.

Abstract:

Aim: This study aims to develop a highly sensitive and specific UPLC-MS/MS method to explore the pharmacokinetic properties of three representative active alkaloids (benzoylhypaconine, benzoylmesaconine, benzoylaconine) after administration of extracts of Aconiti lateralis Radix Praeparata and compatibility with Pinellia, compare the influence of Pinellia on pharmacokinetic characterization of three aconitum alkaloids. Methods: Chromatographic separation were performed on a C18 column under the multiple reaction monitoring (MRM) in the positive electrospray ionization (ESI) mode. The pharmacokinetic parameters were evaluated by software DAS 3. 0. Results: The specificity, precision and accuracy,matrix effect and extraction recovery rate and stability all meet the requirements.The validation of the method was achieved in accordance to the FDA guidelines. After oral administration of the extract, similar tendency was found in the mean concentration of the three analytes in the curves, illustrating that three analytes exhibited a similar absorption and metabolic route. Compared the pharmacokinetic characteristics, the AUC0-t, AUC0-∞ and Cmax values of BMA and BHA in Fuzi group were lower than those in Fuzi-Banxia group. Conclusion: This finding indicated the significant statistical decrease (p<0.05) in the absorption of these components. After Banxia in combination with Fuzi, the results showed that faster absorption and higher exposure of BMA and BHA in rat plasma.

Key words: Pharmacokinetic, Aconiti lateralis Radix, Pinellia, Aconitum alkaloids, UPLC–MS/MS.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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