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Published on:September 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4):670-674
Original Article | doi:10.5530/ijper.53.4.129

In vitro Anti-atherothrombosis Activity of Nigella sativa Oil, Phytol and their Combinations


Authors and affiliation (s):

Muhammad Torequl Islam1,2*, Shamim Molla3, Apu Kumar Das3, Farhana Zaman3, Md. Roich Khan3

1Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.

2Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.

3Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka)-8100, BANGLADESH.

Abstract:

Background: Black seed oil and Phytol (PHY) are evident for their promising biological effects in various test systems. Aim: This study evaluates anti-atherothrombosis activity of Nigella sativa oil (NSO) and Phytol (PHY). Materials and Methods: The clotlysis activity of the NSO and/or PHY has been investigated by taking Streptokinase (SK) as a standard clotlysis drug. Results: The results suggest that the NSO and PHY exhibited a concentration-dependent clotlysis activity in human clotted blood. The highest clotlysis of the NSO and PHY was seen by 57.83 ± 0.23% and 53.05 ± 2.93% with 80 μL and 150 μg per tube, respectively. NSO co-treated with PHY showed a better clotlysis capacity than the NSO and PHY. The vehicle showed negligible clotlysis (2.86 ± 4.33%) capacity, while the standard SK (100 I.U.) showed 78.96 ± 1.08% clotlysis activity. Conclusion: NSO and/or PHY exhibited clotlysis activity in human clotted blood in in vitro.

Key words: Nigella sativa oil, Phytol, Antioxidant, Atherothrombosis, Cardiovascular diseases.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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